Challenges of immune repertoire analysis
Immune repertoire has acquired antigen specificity due to its vast
diversity, but due to its diversity, it has significant problems in
data analysis. V(D) J gene reconfiguration is a
constantly repeated process in individuals, and the receptor sequences
generated and obtained as data are rarely shared between individuals (<1%).
However, the immune response to the same antigen is certainly occurring, which means that molecules with different sequences are responding to the same antigen (epitope) between individuals. In other words, despite the response to the same antigen (epitope), the corresponding receptor sequence data is different between individuals and does not appear to cause the same response on the data.
In other words, the same antigen may be recognized even if the receptor sequence is different, so the need for predicting the three-dimensional structure and specificity of the receptor using AI technology has become clear.